Your browser doesn't support javascript.
loading
ß-Carotene conversion to vitamin A delays atherosclerosis progression by decreasing hepatic lipid secretion in mice.
Zhou, Felix; Wu, Xiaoyun; Pinos, Ivan; Abraham, Benjamin M; Barrett, Tessa J; von Lintig, Johannes; Fisher, Edward A; Amengual, Jaume.
Afiliação
  • Zhou F; Cardiovascular Research Center, Leon H. Charney Division of Cardiology, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA.
  • Wu X; Department of Food Science and Human Nutrition, University of Illinois Urbana Champaign, Urbana, IL, USA.
  • Pinos I; Department of Food Science and Human Nutrition, University of Illinois Urbana Champaign, Urbana, IL, USA.
  • Abraham BM; Division of Nutritional Sciences, University of Illinois Urbana Champaign, Urbana, IL, USA.
  • Barrett TJ; Department of Food Science and Human Nutrition, University of Illinois Urbana Champaign, Urbana, IL, USA.
  • von Lintig J; Cardiovascular Research Center, Leon H. Charney Division of Cardiology, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA.
  • Fisher EA; Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
  • Amengual J; Cardiovascular Research Center, Leon H. Charney Division of Cardiology, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA.
J Lipid Res ; 61(11): 1491-1503, 2020 11.
Article em En | MEDLINE | ID: mdl-32963037
ABSTRACT
Atherosclerosis is characterized by the pathological accumulation of cholesterol-laden macrophages in the arterial wall. Atherosclerosis is also the main underlying cause of CVDs, and its development is largely driven by elevated plasma cholesterol. Strong epidemiological data find an inverse association between plasma ß-carotene with atherosclerosis, and we recently showed that ß-carotene oxygenase 1 (BCO1) activity, responsible for ß-carotene cleavage to vitamin A, is associated with reduced plasma cholesterol in humans and mice. In this study, we explore whether intact ß-carotene or vitamin A affects atherosclerosis progression in the atheroprone LDLR-deficient mice. Compared with control-fed Ldlr-/- mice, ß-carotene-supplemented mice showed reduced atherosclerotic lesion size at the level of the aortic root and reduced plasma cholesterol levels. These changes were absent in Ldlr-/- /Bco1-/- mice despite accumulating ß-carotene in plasma and atherosclerotic lesions. We discarded the implication of myeloid BCO1 in the development of atherosclerosis by performing bone marrow transplant experiments. Lipid production assays found that retinoic acid, the active form of vitamin A, reduced the secretion of newly synthetized triglyceride and cholesteryl ester in cell culture and mice. Overall, our findings provide insights into the role of BCO1 activity and vitamin A in atherosclerosis progression through the regulation of hepatic lipid metabolism.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vitamina A / Beta Caroteno / Aterosclerose / Lipídeos / Fígado Limite: Animals Idioma: En Revista: J Lipid Res Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vitamina A / Beta Caroteno / Aterosclerose / Lipídeos / Fígado Limite: Animals Idioma: En Revista: J Lipid Res Ano de publicação: 2020 Tipo de documento: Article