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Andrographolide and its fluorescent derivative inhibit the main proteases of 2019-nCoV and SARS-CoV through covalent linkage.
Shi, Tzu-Hau; Huang, Yi-Long; Chen, Chiao-Che; Pi, Wen-Chieh; Hsu, Yu-Ling; Lo, Lee-Chiang; Chen, Wei-Yi; Fu, Shu-Ling; Lin, Chao-Hsiung.
Afiliação
  • Shi TH; Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, 112, Taiwan; Biomedical Industry Ph.D. Program, National Yang-Ming University, Taipei, 112, Taiwan.
  • Huang YL; Aging and Health Research Center, National Yang-Ming University, Taipei, 112, Taiwan.
  • Chen CC; Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, 112, Taiwan.
  • Pi WC; Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei, 112, Taiwan.
  • Hsu YL; Department of Chemistry, National Taiwan University, Taipei, 106, Taiwan.
  • Lo LC; Department of Chemistry, National Taiwan University, Taipei, 106, Taiwan.
  • Chen WY; Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei, 112, Taiwan.
  • Fu SL; Institute of Traditional Medicine, National Yang-Ming University, Taipei, 112, Taiwan. Electronic address: slfu@ym.edu.tw.
  • Lin CH; Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, 112, Taiwan; Aging and Health Research Center, National Yang-Ming University, Taipei, 112, Taiwan; Institute of Biopharmaceutical Sciences, National Yang-Ming University, Taipei, 112, Taiwan. Electro
Biochem Biophys Res Commun ; 533(3): 467-473, 2020 Dec 10.
Article em En | MEDLINE | ID: mdl-32977949
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 Base de dados: MEDLINE Assunto principal: Inibidores de Proteases / Cisteína Endopeptidases / Proteínas não Estruturais Virais / Diterpenos Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 Base de dados: MEDLINE Assunto principal: Inibidores de Proteases / Cisteína Endopeptidases / Proteínas não Estruturais Virais / Diterpenos Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2020 Tipo de documento: Article