Design and synthesis of 4-Aminoquinoline-isoindoline-dione-isoniazid triads as potential anti-mycobacterials.
Bioorg Med Chem Lett
; 30(22): 127576, 2020 11 15.
Article
em En
| MEDLINE
| ID: mdl-32980514
ABSTRACT
A series of 4-aminoquinoline-isoindoline-dione-isoniazid triads were synthesized and assessed for their anti-mycobacterial activities and cytotoxicity. Most of the synthesized compounds exhibited promising activities against the mc26230 strain of M. tuberculosis with MIC in the range of 5.1-11.9 µM and were non-cytotoxic against Vero cells. The conjugates lacking either isoniazid or quinoline core in their structural framework failed to inhibit the growth of M. tuberculosis; thus, further strengthening the proposed design of triads in the present study.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Desenho de Fármacos
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Aminoquinolinas
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Indóis
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Isoniazida
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Mycobacterium tuberculosis
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Antituberculosos
Idioma:
En
Revista:
Bioorg Med Chem Lett
Ano de publicação:
2020
Tipo de documento:
Article