[Effects of aerobic exercise and resveratrol on the expressions of JAK2 and TGF-ß1 in renal tissue of type 2 diabetes rats].
Zhongguo Ying Yong Sheng Li Xue Za Zhi
; 36(3): 202-206, 2020 May.
Article
em Zh
| MEDLINE
| ID: mdl-32981272
ABSTRACT
Objective:
To investigate the effects of aerobic exercise and resveratrol on janus kinase 2(JAK2) and transforming growth factor-ß1(TGF-ß1) in renal tissue of type 2 diabetes rats and its mechanism.Methods:
The model of type 2 diabetic rats was established through SD rats fed high-fat diet for 5 weeks together with intraperitoneal infecting after a low dose of STZ. The rats were randomly divided into diabetic control group(DC), diabetic exercise group(DE), diabetic resveratrol group(DR), diabetic exercise and resveratrol group(DER), normal control group(NC), 12 rats in each group. Exercise-related groups performed 8 weeks treadmill exercise (20 m/min, 60 min/day). Resveratrol was administered to drug-related groups for 8 weeks (45 mg/kg, 7 day/week). Eight weeks later, we examined blood glucose concentrations, 24 h microalbuminuria(UA), serum creatinine(Scr), blood urea nitrogen(BUN), and the expressions of TGF-ß1, janus kinase 2(JAK2) and JAK2 mRNA in renal tissue.Results:
After eight weeks of intervention, compared with NC group, the concentrations blood glucose, 24 h UA, Scr, BUN, the expressions of TGF-ß1, JAK2 and JAK2 mRNA were increased significantly in DC group(Pï¼0.05). Compared with DC group, the concentrations of blood glucose, 24 h UA, Scr, BUN, the expressions of TGF-ß1, JAK2 and JAK2 mRNA were decreased significantly in DE group, DR group and DER group(Pï¼0.05).Conclusion:
Exercise, resveratrol and combined intervention may decrease the expressions of JAK2 mRNA, JAK2 and TGF-ß1, which further attenuate renal injury for type 2 diabetes. The renal protective effect produced by exercise and resveratrol combined intervention is better than that produced by exercise or resveratrol intervention alone.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
Base de dados:
MEDLINE
Assunto principal:
Condicionamento Físico Animal
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Regulação da Expressão Gênica
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Diabetes Mellitus Tipo 2
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Janus Quinase 2
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Fator de Crescimento Transformador beta1
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Resveratrol
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Rim
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Revista:
Zhongguo Ying Yong Sheng Li Xue Za Zhi
Ano de publicação:
2020
Tipo de documento:
Article