A Glassy Carbon Electrode for the Determination of Linagliptin, an Antidiabetic Drug in Pure Form, Tablets and Some Biological Fluids by Adsorptive Stripping Voltammetry.
Curr Pharm Des
; 27(20): 2415-2424, 2021.
Article
em En
| MEDLINE
| ID: mdl-32981495
ABSTRACT
AIM:
The present work provides a fast, simple, accurate, and inexpensive analytical method for the determination of Linagliptin (anti-diabetic drug).METHODS:
The analysis was performed using a square wave adsorptive anodic stripping voltammetric technique (SWAASV) and glassy carbon electrode (GCE) as a working electrode. The experimental and instrumental parameters were studied and discussed to ensure the validity of the method.RESULTS:
The method has a very good linearity (R2 = 0.9984), wide concentration range (0.189 - 2.268 µg mL-1), low detection limit of 0.052 µg mL-1 and low quantitation limit of 0.172 µg mL-1.CONCLUSION:
Linagliptin was identified successfully using the proposed method in pharmaceutical formulations, spiked human urine and plasma with 99.67, 91.96, and 92.78% recovery, respectively, and the results obtained were compared with other reported methods.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carbono
/
Linagliptina
Limite:
Humans
Idioma:
En
Revista:
Curr Pharm Des
Ano de publicação:
2021
Tipo de documento:
Article