Discovery, biological evaluation and docking studies of novel N-acyl-2-aminothiazoles fused (+)-nootkatone from Citrus paradisi Macf. as potential &#945;-glucosidase inhibitors.

Guo, Yong; Hou, Enhua; Ma, Nannan; Liu, Zhiyan; Fan, Jiangping; Yang, Ruige

Discovery, biological evaluation and docking studies of novel N-acyl-2-aminothiazoles fused (+)-nootkatone from Citrus paradisi Macf. as potential α-glucosidase inhibitors.

Guo, Yong; Hou, Enhua; Ma, Nannan; Liu, Zhiyan; Fan, Jiangping; Yang, Ruige.

Afiliação

Guo Y; School of Pharmaceutical Sciences, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, No. 100, KeXue Avenue, Zhengzhou 450001, Henan Province, China; State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research
Hou E; School of Pharmaceutical Sciences, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, No. 100, KeXue Avenue, Zhengzhou 450001, Henan Province, China.
Ma N; School of Pharmaceutical Sciences, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, No. 100, KeXue Avenue, Zhengzhou 450001, Henan Province, China.
Liu Z; School of Pharmaceutical Sciences, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, No. 100, KeXue Avenue, Zhengzhou 450001, Henan Province, China.
Fan J; School of Pharmaceutical Sciences, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, No. 100, KeXue Avenue, Zhengzhou 450001, Henan Province, China.
Yang R; School of Pharmaceutical Sciences, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, No. 100, KeXue Avenue, Zhengzhou 450001, Henan Province, China. Electronic address: yrggg@163.com.

Bioorg Chem ; 104: 104294, 2020 11.

Article em En | MEDLINE | ID: mdl-32987307

Assuntos

Citrus paradisi/química; Descoberta de Drogas; Inibidores de Glicosídeo Hidrolases/farmacologia; Simulação de Acoplamento Molecular; Sesquiterpenos Policíclicos/farmacologia; Tiazóis/farmacologia; Relação Dose-Resposta a Droga; Inibidores de Glicosídeo Hidrolases/química; Inibidores de Glicosídeo Hidrolases/isolamento & purificação; Estrutura Molecular; Sesquiterpenos Policíclicos/química; Sesquiterpenos Policíclicos/isolamento & purificação; Saccharomyces cerevisiae/enzimologia; Relação Estrutura-Atividade; Tiazóis/química; Tiazóis/isolamento & purificação; alfa-Glucosidases/metabolismo

Palavras-chave

(+)-Nootkatone; Cytotoxicity; Molecular docking; Thiazole; Type-2 diabetes; α-Glucosidase inhibitor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiazóis / Citrus paradisi / Descoberta de Drogas / Simulação de Acoplamento Molecular / Inibidores de Glicosídeo Hidrolases / Sesquiterpenos Policíclicos Idioma: En Revista: Bioorg Chem Ano de publicação: 2020 Tipo de documento: Article

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