Herpesvirus Epigenetic Reprogramming and Oncogenesis.
Annu Rev Virol
; 7(1): 309-331, 2020 09 29.
Article
em En
| MEDLINE
| ID: mdl-32991266
ABSTRACT
Among all of the known biological carcinogens, Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV) are two of the classical oncogenic herpesviruses known to induce the oncogenic phenotype. Many studies have revealed important functions related to epigenetic alterations of the EBV and KSHV genomes that mediate oncogenesis, but the detailed mechanisms are not fully understood. It is also challenging to fully describe the critical cellular events that drive oncogenesis as well as a comprehensive map of the molecular contributors. This review introduces the roles of epigenetic modifications of these viral genomes, including DNA methylation, histone modification, chromatin remodeling, and noncoding RNA expression, and elucidates potential strategies utilized for inducing oncogenesis by these human gammaherpesviruses.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções Tumorais por Vírus
/
Genoma Viral
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Gammaherpesvirinae
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Infecções por Herpesviridae
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Epigênese Genética
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Carcinogênese
Limite:
Humans
Idioma:
En
Revista:
Annu Rev Virol
Ano de publicação:
2020
Tipo de documento:
Article