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Novel thiobarbiturates as potent urease inhibitors with potential antibacterial activity: Design, synthesis, radiolabeling and biodistribution study.
Abdulwahab, Hanan Gaber; Harras, Marwa F; El Menofy, Nagwan Galal; Hegab, Amany M; Essa, Basma M; Selim, Adli AbdAllah; Sakr, Tamer M; El-Zahabi, Heba S A.
Afiliação
  • Abdulwahab HG; Pharmaceutical Chemistry Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt. Electronic address: hanangaber@azhar.edu.eg.
  • Harras MF; Pharmaceutical Chemistry Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.
  • El Menofy NG; Department of Microbiology and Immunology, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.
  • Hegab AM; Developmental Pharmacology Department, National Organization for Drug Control and Research, Giza, Egypt.
  • Essa BM; Radioactive Isotopes and Generator Department, Hot Laboratories Center, Egyptian Atomic Energy Authority (EAEA), P.O. Box 13759, Cairo, Egypt.
  • Selim AA; Labeled Compounds Department, Hot Labs Center, Egyptian Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt.
  • Sakr TM; Radioactive Isotopes and Generator Department, Hot Laboratories Center, Egyptian Atomic Energy Authority (EAEA), P.O. Box 13759, Cairo, Egypt.
  • El-Zahabi HSA; Pharmaceutical Chemistry Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.
Bioorg Med Chem ; 28(23): 115759, 2020 12 01.
Article em En | MEDLINE | ID: mdl-32992246
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 3_ND Base de dados: MEDLINE Assunto principal: Tiobarbitúricos / Urease / Desenho de Fármacos / Inibidores Enzimáticos / Antibacterianos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Bioorg Med Chem Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 3_ND Base de dados: MEDLINE Assunto principal: Tiobarbitúricos / Urease / Desenho de Fármacos / Inibidores Enzimáticos / Antibacterianos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Bioorg Med Chem Ano de publicação: 2020 Tipo de documento: Article