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Fecal Microbiota Transplant in Two Ulcerative Colitis Pediatric Cases: Gut Microbiota and Clinical Course Correlations.
Quagliariello, Andrea; Del Chierico, Federica; Reddel, Sofia; Russo, Alessandra; Onetti Muda, Andrea; D'Argenio, Patrizia; Angelino, Giulia; Romeo, Erminia Francesca; Dall'Oglio, Luigi; De Angelis, Paola; Putignani, Lorenza.
Afiliação
  • Quagliariello A; Area of Genetics and Rare Diseases, Unit of Human Microbiome, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
  • Del Chierico F; Area of Genetics and Rare Diseases, Unit of Human Microbiome, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
  • Reddel S; Area of Genetics and Rare Diseases, Unit of Human Microbiome, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
  • Russo A; Department of Laboratories, Unit of Parasitology, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
  • Onetti Muda A; Department of Laboratories, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
  • D'Argenio P; Academic Department of Pediatrics, Unit of Immune and Infectious Diseases, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
  • Angelino G; Digestive Surgery and Endoscopy Unit, Bambino Gesù Children's Hospital IRCCS, 00165 Rome, Italy.
  • Romeo EF; Digestive Surgery and Endoscopy Unit, Bambino Gesù Children's Hospital IRCCS, 00165 Rome, Italy.
  • Dall'Oglio L; Digestive Surgery and Endoscopy Unit, Bambino Gesù Children's Hospital IRCCS, 00165 Rome, Italy.
  • De Angelis P; Digestive Surgery and Endoscopy Unit, Bambino Gesù Children's Hospital IRCCS, 00165 Rome, Italy.
  • Putignani L; Department of Laboratories, Unit of Parasitology and Area of Genetics and Rare Diseases, Unit of Human Microbiome, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Microorganisms ; 8(10)2020 Sep 27.
Article em En | MEDLINE | ID: mdl-32992653
ABSTRACT
Fecal microbiota transplantation (FMT) is a promising strategy in the management of inflammatory bowel disease (IBD). The clinical effects of this practice are still largely unknown and unpredictable. In this study, two children affected by mild and moderate ulcerative colitis (UC), were pre- and post-FMT monitored for clinical conditions and gut bacterial ecology. Microbiota profiling relied on receipts' time-point profiles, donors and control cohorts' baseline descriptions. After FMT, the improvement of clinical conditions was recorded for both patients. After 12 months, the mild UC patient was in clinical remission, while the moderate UC patient, after 12 weeks, had a clinical worsening. Ecological analyses highlighted an increase in microbiota richness and phylogenetic distance after FMT. This increase was mainly due to Collinsella aerofaciens and Eubacterium biforme, inherited by respective donors. Moreover, a decrease of Proteus and Blautia producta, and the increment of Parabacteroides, Mogibacteriaceae, Bacteroides eggerthi, Bacteroides plebeius, Ruminococcus bromii, and BBacteroidesovatus were associated with remission of the patient's condition. FMT results in a long-term response in mild UC, while in the moderate form there is probably need for multiple FMT administrations. FMT leads to a decrease in potential pathogens and an increase in microorganisms correlated to remission status.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Microorganisms Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Microorganisms Ano de publicação: 2020 Tipo de documento: Article