AUC, area under the curve; DDA, data-dependent acquisition; DIA, data-independent acquisition; DTT, dithiothreitol; Drug safety; FA, formic acid; FDR, false discovery rate; GABA, gamma-aminobutyric acid; GRX, gingisrex; HAT, histone acetyltransferase; HDACi, histone deacetylase inhibitor; HLB, hypotonic lysis buffer; HPLC, high-performance liquid chromatography; Histone post-translational modifications; K, Lysine; LC-MS/MS; M, Methionine; MS, Mass spectrometry; MS/MS, tandem mass spectrometry; N, asparagine; PBS, phosphate buffered saline; Pharmacoepigenetics; Proteomics; Q, glutamine; R, arginine; RA, relative abundance; RP, reversed phase; RT, room temperature; S, serine; SWATH, sequential window acquisition of all theoretical fragment ion spectra; T, threonine; TEAB, triethylammonium bicarbonate; Toxicoepigenetics; VPA, valproic acid; Y, tyrosine; hESC, human embryonic stem cell; hPTM, histone post-translational modification