Phytochemicals affect T helper 17 and T regulatory cells and gut integrity: implications on the gut-bone axis.
Nutr Res
; 83: 30-48, 2020 11.
Article
em En
| MEDLINE
| ID: mdl-33010588
ABSTRACT
The pathology of osteoporosis is multifactorial, but a growing body of evidence supports an important role of the gut-bone axis, especially in bone loss associated with menopause, rheumatoid arthritis, and periodontal disease. Aberrant T cell responses favoring an increase in the ratio of T helper 17 cells to T regulatory cells play a critical role in the underlying etiology of this bone loss. Many of the dietary phytochemicals known to have osteoprotective activity such as flavonoids, organosulfur compounds, phenolic acids, as well as the oligosaccharides also improve gut barrier function and affect T cell differentiation and activation within gut-associated lymphoid tissues and at distal sites. Here, we examine the potential of these phytochemicals to act as prebiotics and immunomodulating agents, in part targeting the gut to mediate their effects on bone.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Osso e Ossos
/
Linfócitos T Reguladores
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Trato Gastrointestinal
/
Células Th17
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Compostos Fitoquímicos
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Microbioma Gastrointestinal
Limite:
Animals
/
Female
/
Humans
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Male
Idioma:
En
Revista:
Nutr Res
Ano de publicação:
2020
Tipo de documento:
Article