Synthesis, ADMET prediction and reverse screening study of 3,4,5-trimethoxy phenyl ring pendant sulfur-containing cyanopyrimidine derivatives as promising apoptosis inducing anticancer agents.

Nainwal, Lalit Mohan; Shaququzzaman, Mohammad; Akhter, Mymoona; Husain, Asif; Parvez, Suhel; Khan, Farah; Naematullah, Md; Alam, Mohammad Mumtaz

Nainwal, Lalit Mohan; Shaququzzaman, Mohammad; Akhter, Mymoona; Husain, Asif; Parvez, Suhel; Khan, Farah; Naematullah, Md; Alam, Mohammad Mumtaz.

Afiliação

Nainwal LM; Drug Design & Medicinal Chemistry Lab, Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India.
Shaququzzaman M; Drug Design & Medicinal Chemistry Lab, Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India.
Akhter M; Drug Design & Medicinal Chemistry Lab, Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India.
Husain A; Drug Design & Medicinal Chemistry Lab, Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India.
Parvez S; Department of Toxicology, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi 110062, India.
Khan F; Department of Biochemistry, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi 110062, India.
Naematullah M; Department of Biochemistry, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi 110062, India.
Alam MM; Drug Design & Medicinal Chemistry Lab, Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India. Electronic address: mmalam@jamiahamdard.ac.in.

Bioorg Chem ; 104: 104282, 2020 11.

Article em En | MEDLINE | ID: mdl-33010624

Assuntos

Antineoplásicos/farmacologia; Apoptose/efeitos dos fármacos; Pirimidinas/farmacologia; Enxofre/farmacologia; Animais; Antineoplásicos/síntese química; Antineoplásicos/química; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Cães; Relação Dose-Resposta a Droga; Avaliação Pré-Clínica de Medicamentos; Ensaios de Seleção de Medicamentos Antitumorais; Humanos; Células Madin Darby de Rim Canino/efeitos dos fármacos; Estrutura Molecular; Pirimidinas/síntese química; Pirimidinas/química; Relação Estrutura-Atividade; Enxofre/química

Palavras-chave

ADMET studies; Anticancer; Apoptosis; Cyanopyrimidine derivatives; Pyrimidine-5-carbonitrile; Reverse screening; Structure similarity search

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 Base de dados: MEDLINE Assunto principal: Pirimidinas / Enxofre / Apoptose / Antineoplásicos Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Animals / Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2020 Tipo de documento: Article

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