[Effect of trimebutine on the plasma postprandial release of gastrointestinal hormones in the dog]. / Effet de la trimébutine sur la libération plasmatique postprandiale d'hormones gastrointestinales chez le chien.
Gastroenterol Clin Biol
; 11(3 Pt 2): 94B-96B, 1987.
Article
em Fr
| MEDLINE
| ID: mdl-3301510
ABSTRACT
The injection of trimebutine induces in the dog an increase of plasma motilin during the fasting period as well as after a meal. We studied the effect of trimebutine on several gastrointestinal hormones released into the circulation by the ingestion of a meal. The intravenous administration of trimebutine (10 mg/kg/h) in 4 dogs abolished the postprandial increase in plasma gastrin, pancreatic polypeptide, insulin, glucagon and GIP. Trimebutine could therefore, by its effects on various regulatory peptides, influence several digestive functions. Its mode of action could probably involves complex mechanisms, including paradoxical effects. The possibility that motilin is a mediator of the trimebutine effect on small bowel smooth muscle is discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Trimebutina
/
Benzoatos
/
Hormônios Gastrointestinais
Limite:
Animals
Idioma:
Fr
Revista:
Gastroenterol Clin Biol
Ano de publicação:
1987
Tipo de documento:
Article