Asymptomatic brainstem lesions and pachymeningeal enhancement after anti-PD-1 therapy.
Immunotherapy
; 13(1): 11-17, 2021 01.
Article
em En
| MEDLINE
| ID: mdl-33023359
ABSTRACT
Neurological immune-related adverse events (irAEs) are rare toxicities that occur following immune checkpoint inhibitor therapy. We propose that patients with thymic malignancies and graft-versus-host disease (GVHD) are predisposed to irAEs. We present two asymptomatic patients, one with thymoma and another with GVHD, who developed abnormal brain MRIs after treatment with programmed cell death protein 1 inhibitors. The first patient, with thymic cancer and thymoma, developed pontine enhancing MRI lesions following treatment with pembrolizumab. The second patient, with prior GVHD, developed pachymeningeal enhancement following treatment with nivolumab. IrAEs with abnormal MRI studies, despite asymptomatology, have significant impact on the treatment strategy for these patients.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
/
3_ND
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4_TD
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6_ODS3_enfermedades_notrasmisibles
Base de dados:
MEDLINE
Assunto principal:
Timoma
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Neoplasias do Timo
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Neoplasias Encefálicas
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Receptor de Morte Celular Programada 1
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Inibidores de Checkpoint Imunológico
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Doença Enxerto-Hospedeiro
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Meningite
Limite:
Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Immunotherapy
Ano de publicação:
2021
Tipo de documento:
Article