Mechanistic insights into transition metal-mediated bioorthogonal uncaging reactions.
Chem Soc Rev
; 49(21): 7710-7729, 2020 Nov 07.
Article
em En
| MEDLINE
| ID: mdl-33026001
ABSTRACT
Cleavage of C-O and C-N bonds mediated by transition metals is a promising bioorthogonal approach to rescue the activity of caged molecules, such as proteins and cytotoxic drugs, under biological conditions. However, the precise mechanism of such uncaging reactions remains elusive. This review provides mechanistic insights into metal-mediated bond-cleavage reactions, with the goals of understanding the main factors that influence the reaction and aiding the rational development of new caging groups/catalysts for chemical biology and drug-delivery applications.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Orgânicos
/
Elementos de Transição
Idioma:
En
Revista:
Chem Soc Rev
Ano de publicação:
2020
Tipo de documento:
Article