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Molecular evolutionary and structural analysis of human UCHL1 gene demonstrates the relevant role of intragenic epistasis in Parkinson's disease and other neurological disorders.
Nawaz, Muhammad Saqib; Asghar, Razia; Pervaiz, Nashaiman; Ali, Shahid; Hussain, Irfan; Xing, Peiqi; Bao, Yiming; Abbasi, Amir Ali.
Afiliação
  • Nawaz MS; National Center for Bioinformatics, Program of Comparative and Evolutionary Genomics, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan.
  • Asghar R; National Center for Bioinformatics, Program of Comparative and Evolutionary Genomics, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan.
  • Pervaiz N; National Center for Bioinformatics, Program of Comparative and Evolutionary Genomics, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan.
  • Ali S; National Center for Bioinformatics, Program of Comparative and Evolutionary Genomics, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan.
  • Hussain I; National Center for Bioinformatics, Program of Comparative and Evolutionary Genomics, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan.
  • Xing P; National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, 100101, China.
  • Bao Y; University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Abbasi AA; National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, 100101, China. baoym@big.ac.cn.
BMC Evol Biol ; 20(1): 130, 2020 10 07.
Article em En | MEDLINE | ID: mdl-33028204
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Evolução Molecular / Ubiquitina Tiolesterase / Epistasia Genética Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: BMC Evol Biol Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Evolução Molecular / Ubiquitina Tiolesterase / Epistasia Genética Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: BMC Evol Biol Ano de publicação: 2020 Tipo de documento: Article