Extracellular SQSTM1 mediates bacterial septic death in mice through insulin receptor signalling.

Zhou, Borong; Liu, Jiao; Zeng, Ling; Zhu, Shan; Wang, Haichao; Billiar, Timothy R; Kroemer, Guido; Klionsky, Daniel J; Zeh, Herbert J; Jiang, Jianxin; Tang, Daolin; Kang, Rui

Zhou, Borong; Liu, Jiao; Zeng, Ling; Zhu, Shan; Wang, Haichao; Billiar, Timothy R; Kroemer, Guido; Klionsky, Daniel J; Zeh, Herbert J; Jiang, Jianxin; Tang, Daolin; Kang, Rui.

Afiliação

Zhou B; The Third Affiliated Hospital, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, Guangzhou Medical University, Guangzhou, China.
Liu J; The Third Affiliated Hospital, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, Guangzhou Medical University, Guangzhou, China.
Zeng L; State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Army Medical University, Chongqing, China.
Zhu S; Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, China.
Wang H; Laboratory of Emergency Medicine, North Shore University Hospital and the Feinstein Institute for Medical Research, Manhasset, NY, USA.
Billiar TR; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Kroemer G; Equipe Labellisée par la Ligue Contre le Cancer, Université de Paris, Sorbonne Université, Institut National de la Santé et de la Recherche Médicale U1138, Centre de Recherche des Cordeliers, Paris, France.
Klionsky DJ; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France.
Zeh HJ; Pôle de Biologie, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France.
Jiang J; Suzhou Institute for Systems Medicine, Chinese Academy of Sciences, Suzhou, China.
Tang D; Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden.
Kang R; Life Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.

Nat Microbiol ; 5(12): 1576-1587, 2020 12.

Article em En | MEDLINE | ID: mdl-33077977

Assuntos

Bacteriemia/metabolismo; Bacteriemia/mortalidade; Receptor de Insulina/metabolismo; Proteína Sequestossoma-1/metabolismo; Animais; Bacteriemia/genética; Bacteriemia/microbiologia; Bactérias/classificação; Bactérias/genética; Bactérias/isolamento & purificação; Escherichia coli/fisiologia; Feminino; Humanos; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Monócitos/metabolismo; Células Mieloides/metabolismo; NF-kappa B/genética; NF-kappa B/metabolismo; Receptor de Insulina/genética; Proteína Sequestossoma-1/genética; Transdução de Sinais; Streptococcus pneumoniae/fisiologia

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 3_ND Base de dados: MEDLINE Assunto principal: Receptor de Insulina / Bacteriemia / Proteína Sequestossoma-1 Limite: Animals / Female / Humans / Male Idioma: En Revista: Nat Microbiol Ano de publicação: 2020 Tipo de documento: Article

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