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Discovery of OATD-01, a First-in-Class Chitinase Inhibitor as Potential New Therapeutics for Idiopathic Pulmonary Fibrosis.
Koralewski, Robert; Dymek, Barbara; Mazur, Marzena; Sklepkiewicz, Piotr; Olejniczak, Sylwia; Czestkowski, Wojciech; Matyszewski, Krzysztof; Andryianau, Gleb; Niedziejko, Piotr; Kowalski, Michal; Gruza, Mariusz; Borek, Bartlomiej; Jedrzejczak, Karol; Bartoszewicz, Agnieszka; Pluta, Elzbieta; Rymaszewska, Aleksandra; Kania, Magdalena; Rejczak, Tomasz; Piasecka, Sylwia; Mlacki, Michal; Mazurkiewicz, Marcin; Piotrowicz, Michal; Salamon, Magdalena; Zagozdzon, Agnieszka; Napiorkowska-Gromadzka, Agnieszka; Bartlomiejczak, Aneta; Mozga, Witold; Dobrzanski, Pawel; Dzwonek, Karolina; Golab, Jakub; Nowotny, Marcin; Olczak, Jacek; Golebiowski, Adam.
Afiliação
  • Koralewski R; OncoArendi Therapeutics SA, Zwirki i Wigury 101, 02-089 Warsaw, Poland.
  • Dymek B; OncoArendi Therapeutics SA, Zwirki i Wigury 101, 02-089 Warsaw, Poland.
  • Mazur M; OncoArendi Therapeutics SA, Zwirki i Wigury 101, 02-089 Warsaw, Poland.
  • Sklepkiewicz P; OncoArendi Therapeutics SA, Zwirki i Wigury 101, 02-089 Warsaw, Poland.
  • Olejniczak S; OncoArendi Therapeutics SA, Zwirki i Wigury 101, 02-089 Warsaw, Poland.
  • Czestkowski W; OncoArendi Therapeutics SA, Zwirki i Wigury 101, 02-089 Warsaw, Poland.
  • Matyszewski K; OncoArendi Therapeutics SA, Zwirki i Wigury 101, 02-089 Warsaw, Poland.
  • Andryianau G; OncoArendi Therapeutics SA, Zwirki i Wigury 101, 02-089 Warsaw, Poland.
  • Niedziejko P; OncoArendi Therapeutics SA, Zwirki i Wigury 101, 02-089 Warsaw, Poland.
  • Kowalski M; OncoArendi Therapeutics SA, Zwirki i Wigury 101, 02-089 Warsaw, Poland.
  • Gruza M; OncoArendi Therapeutics SA, Zwirki i Wigury 101, 02-089 Warsaw, Poland.
  • Borek B; OncoArendi Therapeutics SA, Zwirki i Wigury 101, 02-089 Warsaw, Poland.
  • Jedrzejczak K; OncoArendi Therapeutics SA, Zwirki i Wigury 101, 02-089 Warsaw, Poland.
  • Bartoszewicz A; OncoArendi Therapeutics SA, Zwirki i Wigury 101, 02-089 Warsaw, Poland.
  • Pluta E; OncoArendi Therapeutics SA, Zwirki i Wigury 101, 02-089 Warsaw, Poland.
  • Rymaszewska A; OncoArendi Therapeutics SA, Zwirki i Wigury 101, 02-089 Warsaw, Poland.
  • Kania M; OncoArendi Therapeutics SA, Zwirki i Wigury 101, 02-089 Warsaw, Poland.
  • Rejczak T; OncoArendi Therapeutics SA, Zwirki i Wigury 101, 02-089 Warsaw, Poland.
  • Piasecka S; OncoArendi Therapeutics SA, Zwirki i Wigury 101, 02-089 Warsaw, Poland.
  • Mlacki M; OncoArendi Therapeutics SA, Zwirki i Wigury 101, 02-089 Warsaw, Poland.
  • Mazurkiewicz M; OncoArendi Therapeutics SA, Zwirki i Wigury 101, 02-089 Warsaw, Poland.
  • Piotrowicz M; OncoArendi Therapeutics SA, Zwirki i Wigury 101, 02-089 Warsaw, Poland.
  • Salamon M; OncoArendi Therapeutics SA, Zwirki i Wigury 101, 02-089 Warsaw, Poland.
  • Zagozdzon A; OncoArendi Therapeutics SA, Zwirki i Wigury 101, 02-089 Warsaw, Poland.
  • Napiorkowska-Gromadzka A; Structural Biology Center, International Institute of Molecular and Cell Biology, Trojdena 4, 02-109 Warsaw, Poland.
  • Bartlomiejczak A; Structural Biology Center, International Institute of Molecular and Cell Biology, Trojdena 4, 02-109 Warsaw, Poland.
  • Mozga W; OncoArendi Therapeutics SA, Zwirki i Wigury 101, 02-089 Warsaw, Poland.
  • Dobrzanski P; OncoArendi Therapeutics SA, Zwirki i Wigury 101, 02-089 Warsaw, Poland.
  • Dzwonek K; OncoArendi Therapeutics SA, Zwirki i Wigury 101, 02-089 Warsaw, Poland.
  • Golab J; OncoArendi Therapeutics SA, Zwirki i Wigury 101, 02-089 Warsaw, Poland.
  • Nowotny M; Department of Immunology, Medical University of Warsaw, Nielubowicza 5, 02-097 Warsaw, Poland.
  • Olczak J; Structural Biology Center, International Institute of Molecular and Cell Biology, Trojdena 4, 02-109 Warsaw, Poland.
  • Golebiowski A; OncoArendi Therapeutics SA, Zwirki i Wigury 101, 02-089 Warsaw, Poland.
J Med Chem ; 63(24): 15527-15540, 2020 12 24.
Article em En | MEDLINE | ID: mdl-33078933
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperidinas / Quitinases / Inibidores Enzimáticos / Fibrose Pulmonar Idiopática Limite: Animals / Female / Humans Idioma: En Revista: J Med Chem Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperidinas / Quitinases / Inibidores Enzimáticos / Fibrose Pulmonar Idiopática Limite: Animals / Female / Humans Idioma: En Revista: J Med Chem Ano de publicação: 2020 Tipo de documento: Article