Copper-Catalyzed Trifluoromethylation of Alkoxypyridine Derivatives.
Molecules
; 25(20)2020 Oct 16.
Article
em En
| MEDLINE
| ID: mdl-33081411
ABSTRACT
The trifluoromethylation of aromatic and heteroaromatic cores has attracted considerable interest in recent years due to its pharmacological relevance. We studied the extension of a simple copper-catalyzed trifluoromethylation protocol to alkoxy-substituted iodopyridines and their benzologs. The trifluoromethylation proceeded smoothly in all cases, and the desired compounds were isolated and characterized. In the trifluoromethylation of 3-iodo-4-methoxyquinoline, we observed a concomitant O-N methyl migration, resulting in the trifluoromethylated quinolone as a product. Overall, the described procedure should facilitate the broader use of copper-catalyzed trifluoromethylation in medicinal chemistry.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cobre
/
Alcenos
/
Hidrocarbonetos Fluorados
Idioma:
En
Revista:
Molecules
Ano de publicação:
2020
Tipo de documento:
Article