Focus on MicroRNAs as Biomarker in Pediatric Diseases.
Curr Pharm Des
; 27(6): 826-832, 2021.
Article
em En
| MEDLINE
| ID: mdl-33087027
ABSTRACT
BACKGROUND:
MiRNAs are a class of small non-coding RNAs that are involved in the post-transcriptional regulation of gene expression. MiRNAs are considered a class of epigenetic biomarkers. These biomarkers can investigate disease at different stages diagnosis, therapy or clinical follow-up.OBJECTIVE:
The aim of this paper is to highlight the innovative use of miRNAs in several childhood diseases.METHODS:
We conducted a literature review to search the usage of miRNAs in pediatric clinical routine or experimental trials.RESULTS:
We found a possible key role of miRNAs in different pediatric illnesses (metabolic alterations, coagulation defects, cancer).CONCLUSION:
The modest literature production denotes that further investigation is needed to assess and validate the promising role of miRNAs as non-invasive biomarkers in pediatric disorders.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
MicroRNAs
/
Neoplasias
Tipo de estudo:
Diagnostic_studies
Limite:
Child
/
Humans
Idioma:
En
Revista:
Curr Pharm Des
Ano de publicação:
2021
Tipo de documento:
Article