Roles of NAD+ and Its Metabolites Regulated Calcium Channels in Cancer.
Molecules
; 25(20)2020 Oct 20.
Article
em En
| MEDLINE
| ID: mdl-33092205
ABSTRACT
Nicotinamide adenine dinucleotide (NAD+) is an essential cofactor for redox enzymes, but also moonlights as a regulator for ion channels, the same as its metabolites. Ca2+ homeostasis is dysregulated in cancer cells and affects processes such as tumorigenesis, angiogenesis, autophagy, progression, and metastasis. Herein, we summarize the regulation of the most common calcium channels (TRPM2, TPCs, RyRs, and TRPML1) by NAD+ and its metabolites, with a particular focus on their roles in cancers. Although the mechanisms of NAD+ metabolites in these pathological processes are yet to be clearly elucidated, these ion channels are emerging as potential candidates of alternative targets for anticancer therapy.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Canais de Cálcio
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Cálcio
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NAD
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Neoplasias
Limite:
Humans
Idioma:
En
Revista:
Molecules
Ano de publicação:
2020
Tipo de documento:
Article