Imperatorin Alleviates Psoriasiform Dermatitis by Blocking Neutrophil Respiratory Burst, Adhesion, and Chemotaxis Through Selective Phosphodiesterase 4 Inhibition.

Tsai, Yung-Fong; Chen, Chun-Yu; Lin, I-Wen; Leu, Yann-Lii; Yang, Shun-Chin; Syu, Yu-Ting; Chen, Po-Jen; Hwang, Tsong-Long

Tsai, Yung-Fong; Chen, Chun-Yu; Lin, I-Wen; Leu, Yann-Lii; Yang, Shun-Chin; Syu, Yu-Ting; Chen, Po-Jen; Hwang, Tsong-Long.

Afiliação

Tsai YF; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Chen CY; Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Lin IW; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Leu YL; Department of Anesthesiology, Xiamen Chang Gung Hospital, Xiamen, China.
Yang SC; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Syu YT; Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Chen PJ; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Hwang TL; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Antioxid Redox Signal ; 35(11): 885-903, 2021 10 10.

Article em En | MEDLINE | ID: mdl-33107318

Assuntos

Quimiotaxia/efeitos dos fármacos; Dermatite/tratamento farmacológico; Furocumarinas/farmacologia; Neutrófilos/efeitos dos fármacos; Inibidores da Fosfodiesterase 4/farmacologia; Explosão Respiratória/efeitos dos fármacos; Adulto; Animais; Adesão Celular/efeitos dos fármacos; Feminino; Humanos; Imiquimode; Masculino; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Endogâmicos C57BL; Neutrófilos/metabolismo; Adulto Jovem

Palavras-chave

PDE4 inhibitor; imperatorin; neutrophil; psoriasis; superoxide anion

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Furocumarinas / Quimiotaxia / Explosão Respiratória / Dermatite / Inibidores da Fosfodiesterase 4 / Neutrófilos Limite: Adult / Animals / Female / Humans / Male Idioma: En Revista: Antioxid Redox Signal Ano de publicação: 2021 Tipo de documento: Article

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