Synthesis of Bacterial-Derived Peptidoglycan Cross-Linked Fragments.
J Org Chem
; 85(24): 16243-16253, 2020 12 18.
Article
em En
| MEDLINE
| ID: mdl-33108204
ABSTRACT
Peptidoglycan (PG) is the core structural motif of the bacterial cell wall. Fragments released from the PG serve as fundamental recognition elements for the immune system. The structure of the PG, however, encompasses a variety of chemical modifications among different bacterial species. Here, the applicability of organic synthetic methods to address this chemical diversity is explored, and the synthesis of cross-linked PG fragments, carrying biologically relevant amino acid modifications and peptide cross-linkages, is presented using solution and solid phase approaches.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptidoglicano
/
Parede Celular
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2020
Tipo de documento:
Article