[Gastro-oesophageal reflux disease-update 2021]. / Gastroösophageale Refluxkrankheit Update 2021.
Internist (Berl)
; 61(12): 1249-1263, 2020 Dec.
Article
em De
| MEDLINE
| ID: mdl-33112963
ABSTRACT
Gastro-oesophageal reflux disease (GORD), a highly prevalent disease, is defined by troublesome symptoms and/or oesophageal lesions caused by reflux of gastric content. A diagnostic gold standard does not exist. A reliable diagnosis may be difficult in individual cases. Patients' history, endoscopic findings and pH-impedance monitoring contribute to the evaluation of gastro-oesophageal reflux and its consequences. High-resolution manometry may add important information on the pathophysiology of the disease and may help to rule out motility disorders as the leading cause of the symptoms. Proton pump inhibitors (PPI) are the drugs of first choice. In patients with insufficient PPI response, optimization of PPI therapy and/or combination with drugs having another mechanism of action are the available options. If PPIs are not sufficiently effective, not tolerated, or not wished antireflux procedures may be offered in specialized centers taking pathophysiological data into account.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Refluxo Gastroesofágico
/
Inibidores da Bomba de Prótons
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
De
Revista:
Internist (Berl)
Ano de publicação:
2020
Tipo de documento:
Article