Preparation and identification of an anti-idiotypic antibody antagonist (FG8) for EGFR that shows potential activity against liver cancer cells.

Wang, Yurong; He, Fangping; Zhang, Helin; Cao, Ying; Zhang, Yaqing; Ling, Yun; Rehati, Aliya

Wang, Yurong; He, Fangping; Zhang, Helin; Cao, Ying; Zhang, Yaqing; Ling, Yun; Rehati, Aliya.

Afiliação

Wang Y; Digestive Systerm Deparment, The Affiliated Hospital of Dalian Medical University, Central Hospital of Huludao City, Huludao, 125000, Liaoning, China.
He F; Department of Gastroenternology II, The First Affiliated Hospital of Xinjiang Medical University, Xinjiang Uygur Autonomous Regions, Ürümqi, 830011, China.
Zhang H; Digestive Systerm Deparment, The Affiliated Hospital of Dalian Medical University, Central Hospital of Huludao City, Huludao, 125000, Liaoning, China.
Cao Y; Digestive Systerm Deparment, The Affiliated Hospital of Dalian Medical University, Central Hospital of Huludao City, Huludao, 125000, Liaoning, China.
Zhang Y; Digestive Systerm Deparment, The Affiliated Hospital of Dalian Medical University, Central Hospital of Huludao City, Huludao, 125000, Liaoning, China.
Ling Y; Digestive Systerm Deparment, The Affiliated Hospital of Dalian Medical University, Central Hospital of Huludao City, Huludao, 125000, Liaoning, China.
Rehati A; Department of Gastroenternology II, The First Affiliated Hospital of Xinjiang Medical University, Xinjiang Uygur Autonomous Regions, Ürümqi, 830011, China. Aliyaxinjiang@aliyun.com.

Biotechnol Lett ; 43(2): 369-382, 2021 Feb.

Article em En | MEDLINE | ID: mdl-33141321

Assuntos

Anticorpos Anti-Idiotípicos/biossíntese; Antineoplásicos/farmacologia; Neoplasias Hepáticas/tratamento farmacológico; Anticorpos Anti-Idiotípicos/efeitos dos fármacos; Anticorpos Anti-Idiotípicos/imunologia; Antineoplásicos/química; Apoptose/efeitos dos fármacos; Ligação Competitiva/efeitos dos fármacos; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Ensaio de Imunoadsorção Enzimática; Epitopos/efeitos dos fármacos; Epitopos/genética; Receptores ErbB/antagonistas & inibidores; Receptores ErbB/genética; Receptores ErbB/imunologia; Humanos; Neoplasias Hepáticas/genética; Neoplasias Hepáticas/imunologia; Neoplasias Hepáticas/patologia; Ligação Proteica/genética; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

Antagonist; Anti-idiotypic antibody; EGFR; Liver cancer; Signalling pathway

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anticorpos Anti-Idiotípicos / Neoplasias Hepáticas / Antineoplásicos Tipo de estudo: Diagnostic_studies / Guideline / Prognostic_studies Limite: Humans Idioma: En Revista: Biotechnol Lett Ano de publicação: 2021 Tipo de documento: Article

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