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Integrated digital pathology and transcriptome analysis identifies molecular mediators of T-cell exclusion in ovarian cancer.
Desbois, Mélanie; Udyavar, Akshata R; Ryner, Lisa; Kozlowski, Cleopatra; Guan, Yinghui; Dürrbaum, Milena; Lu, Shan; Fortin, Jean-Philippe; Koeppen, Hartmut; Ziai, James; Chang, Ching-Wei; Keerthivasan, Shilpa; Plante, Marie; Bourgon, Richard; Bais, Carlos; Hegde, Priti; Daemen, Anneleen; Turley, Shannon; Wang, Yulei.
Afiliação
  • Desbois M; Department of Oncology Biomarker Development, Genentech, Inc., South San Francisco, CA, USA.
  • Udyavar AR; Department of Bioinformatics & Computational Biology, Genentech, Inc., South San Francisco, CA, USA.
  • Ryner L; Department of Oncology Biomarker Development, Genentech, Inc., South San Francisco, CA, USA.
  • Kozlowski C; Department of Oncology Biomarker Development, Genentech, Inc., South San Francisco, CA, USA.
  • Guan Y; Department of Oncology Biomarker Development, Genentech, Inc., South San Francisco, CA, USA.
  • Dürrbaum M; Department of Bioinformatics & Computational Biology, Genentech, Inc., South San Francisco, CA, USA.
  • Lu S; Department of Oncology Biomarker Development, Genentech, Inc., South San Francisco, CA, USA.
  • Fortin JP; Department of Bioinformatics & Computational Biology, Genentech, Inc., South San Francisco, CA, USA.
  • Koeppen H; Department of Research Pathology, Genentech, Inc., South San Francisco, CA, USA.
  • Ziai J; Department of Research Pathology, Genentech, Inc., South San Francisco, CA, USA.
  • Chang CW; Department of Biostatistics, Genentech, Inc., South San Francisco, CA, USA.
  • Keerthivasan S; Department of Cancer Immunology, Genentech, Inc., South San Francisco, CA, USA.
  • Plante M; Laval University Cancer Research Center, Hôtel-Dieu-de-Québec, Centre Hospitalier Universitaire (CHU) de Québec, 11 Côte du Palais, Québec, QC, G1R 2J6, Canada.
  • Bourgon R; Department of Bioinformatics & Computational Biology, Genentech, Inc., South San Francisco, CA, USA.
  • Bais C; Department of Oncology Biomarker Development, Genentech, Inc., South San Francisco, CA, USA.
  • Hegde P; Department of Oncology Biomarker Development, Genentech, Inc., South San Francisco, CA, USA.
  • Daemen A; Department of Bioinformatics & Computational Biology, Genentech, Inc., South San Francisco, CA, USA.
  • Turley S; Department of Cancer Immunology, Genentech, Inc., South San Francisco, CA, USA.
  • Wang Y; Department of Oncology Biomarker Development, Genentech, Inc., South San Francisco, CA, USA. wang.yulei@gene.com.
Nat Commun ; 11(1): 5583, 2020 11 04.
Article em En | MEDLINE | ID: mdl-33149148
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Regulação Neoplásica da Expressão Gênica / Fator de Crescimento Transformador beta / Linfócitos T CD8-Positivos / Microambiente Tumoral / Carcinoma Epitelial do Ovário Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Revista: Nat Commun Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Regulação Neoplásica da Expressão Gênica / Fator de Crescimento Transformador beta / Linfócitos T CD8-Positivos / Microambiente Tumoral / Carcinoma Epitelial do Ovário Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Revista: Nat Commun Ano de publicação: 2020 Tipo de documento: Article