The OGTT is highly reproducible in Africans for the diagnosis of diabetes: Implications for treatment and protocol design.

Jagannathan, Ram; DuBose, Christopher W; Mabundo, Lilian S; Chung, Stephanie T; Ha, Joon; Sherman, Arthur; Bergman, Michael; Sumner, Anne E

Jagannathan, Ram; DuBose, Christopher W; Mabundo, Lilian S; Chung, Stephanie T; Ha, Joon; Sherman, Arthur; Bergman, Michael; Sumner, Anne E.

Afiliação

Jagannathan R; Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States.
DuBose CW; Section on Ethnicity and Health, Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, United States.
Mabundo LS; Section on Ethnicity and Health, Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, United States.
Chung ST; Section on Ethnicity and Health, Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, United States.
Ha J; Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States.
Sherman A; Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States.
Bergman M; Division of Endocrinology and Metabolism, Department of Medicine and of Population Health, New York University School of Medicine, New York, NY, United States.
Sumner AE; Section on Ethnicity and Health, Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, United States; National Institute of Minority Health and Health Disparities, National Institutes of Health, Bethesda, MD, United States. Electronic address:

Diabetes Res Clin Pract ; 170: 108523, 2020 Dec.

Article em En | MEDLINE | ID: mdl-33153960

RESUMO

Whether an OGTT reproducibly detects either type 2 diabetes (T2D) or prediabetes in Africans in unknown. Therefore, 131 Africans had two OGTT. Diagnostic reproducibility for T2D was excellent (κ = 0.84), but only moderate for prediabetes (κ = 0.51). A single OGTT positive for T2D may be sufficient to guide clinical care and inform epidemiologic study design. ClinicalTrials.gov Identifier: NCT00001853.

Assuntos

Glicemia/metabolismo; Diabetes Mellitus Tipo 2/diagnóstico; Teste de Tolerância a Glucose/métodos; Adulto; África; Idoso; Feminino; Humanos; Masculino; Pessoa de Meia-Idade; Reprodutibilidade dos Testes; Adulto Jovem

Palavras-chave

Africans; Diabetes; Fasting plasma glucose; OGTT

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicemia / Diabetes Mellitus Tipo 2 / Teste de Tolerância a Glucose Tipo de estudo: Diagnostic_studies / Guideline / Prognostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: Africa Idioma: En Revista: Diabetes Res Clin Pract Ano de publicação: 2020 Tipo de documento: Article

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