Alveolar and lung interstitial macrophages: Definitions, functions, and roles in lung fibrosis.
J Leukoc Biol
; 110(1): 107-114, 2021 07.
Article
em En
| MEDLINE
| ID: mdl-33155728
ABSTRACT
MÏs are the main innate immune cells in the lung at homeostasis, with important roles in host defence and immune modulation. Alveolar MÏs (AMs) and interstitial MÏs (IMs) are the two lung MÏ subsets, so called according to the sites they reside in. These subsets are also defined by their origins and immunological microenvironment, which endow these cells with distinct features and plasticity. This review summarizes the latest definitions and functions of lung MÏs during homeostasis and provides exemplar of their divergent roles in lung fibrosis.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Alvéolos Pulmonares
/
Macrófagos Alveolares
/
Imunidade Inata
Tipo de estudo:
Etiology_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Leukoc Biol
Ano de publicação:
2021
Tipo de documento:
Article