Application of physiologically based pharmacokinetic modeling for sertraline dosing recommendations in pregnancy.

George, Blessy; Lumen, Annie; Nguyen, Christine; Wesley, Barbara; Wang, Jian; Beitz, Julie; Crentsil, Victor

George, Blessy; Lumen, Annie; Nguyen, Christine; Wesley, Barbara; Wang, Jian; Beitz, Julie; Crentsil, Victor.

Afiliação

George B; Center for Drug Evaluation and Research, U.S. FDA, Silver Spring, MD, USA.
Lumen A; Oak Ridge Institute for Science and Education, Oak Ridge, TN, USA.
Nguyen C; National Center for Toxicological Research, U.S. FDA, Jefferson, AR, USA.
Wesley B; Center for Drug Evaluation and Research, U.S. FDA, Silver Spring, MD, USA.
Wang J; Center for Drug Evaluation and Research, U.S. FDA, Silver Spring, MD, USA.
Beitz J; Center for Drug Evaluation and Research, U.S. FDA, Silver Spring, MD, USA.
Crentsil V; Center for Drug Evaluation and Research, U.S. FDA, Silver Spring, MD, USA.

NPJ Syst Biol Appl ; 6(1): 36, 2020 11 06.

Article em En | MEDLINE | ID: mdl-33159093

Assuntos

Modelos Biológicos; Sertralina/farmacocinética; Relação Dose-Resposta a Droga; Feminino; Humanos; Placenta/efeitos dos fármacos; Placenta/metabolismo; Gravidez; Sertralina/farmacologia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sertralina / Modelos Biológicos Tipo de estudo: Prognostic_studies Limite: Female / Humans / Pregnancy Idioma: En Revista: NPJ Syst Biol Appl Ano de publicação: 2020 Tipo de documento: Article

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