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Inhibition of histamine receptor H3 suppresses the growth and metastasis of human non-small cell lung cancer cells via inhibiting PI3K/Akt/mTOR and MEK/ERK signaling pathways and blocking EMT.
Zhao, Yan-Yan; Jia, Jing; Zhang, Jing-Jing; Xun, Yan-Ping; Xie, Shu-Jun; Liang, Jia-Feng; Guo, Hong-Gang; Zhu, Jia-Zhen; Ma, Sheng-Lin; Zhang, Shi-Rong.
Afiliação
  • Zhao YY; Department of Translation Medicine Center, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China.
  • Jia J; Center for Molecular Medicine, Zhejiang Academy of Medical Sciences, Hangzhou, 310006, China.
  • Zhang JJ; Department of Translation Medicine Center, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China.
  • Xun YP; Department of Translation Medicine Center, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China.
  • Xie SJ; Department of Translation Medicine Center, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China.
  • Liang JF; Department of Translation Medicine Center, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China.
  • Guo HG; Center for Molecular Medicine, Zhejiang Academy of Medical Sciences, Hangzhou, 310006, China.
  • Zhu JZ; College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, 310006, China.
  • Ma SL; Department of Translation Medicine Center, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China. mashenglin@medmail.com.cn.
  • Zhang SR; Department of Oncology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China. mashenglin@medmail.com.cn.
Acta Pharmacol Sin ; 42(8): 1288-1297, 2021 Aug.
Article em En | MEDLINE | ID: mdl-33159174
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Receptores Histamínicos H3 / Sistema de Sinalização das MAP Quinases / Transição Epitelial-Mesenquimal / Antagonistas dos Receptores Histamínicos / Imidazóis / Antineoplásicos Limite: Humans Idioma: En Revista: Acta Pharmacol Sin Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Receptores Histamínicos H3 / Sistema de Sinalização das MAP Quinases / Transição Epitelial-Mesenquimal / Antagonistas dos Receptores Histamínicos / Imidazóis / Antineoplásicos Limite: Humans Idioma: En Revista: Acta Pharmacol Sin Ano de publicação: 2021 Tipo de documento: Article