Comparative study of dietary fat: lard and sugar as a better obesity and metabolic syndrome mice model.
Arch Physiol Biochem
; 129(2): 449-459, 2023 Apr.
Article
em En
| MEDLINE
| ID: mdl-33176505
ABSTRACT
BACKGROUND:
Diet macronutrient heterogeneity hinders animal studies' data extrapolation from metabolic disorders to human diseases.OBJECTIVE:
The present study aimed to evaluate different fat-diet compositions' effect on inducing lipid/glucose metabolism alterations in mice.METHODS:
Swiss male mice were fed for 12 weeks with five different diets Standard Diet (ST), American Institute of Nutrition 93 for growth (AIN93G) high-butter/high-sugar (HBHS), high-lard/high-sugar (HLHS), and high-oil/high-sugar diet (soybean oil) (HOHS). Several parameters, such as serum biochemistry, histology, and liver mRNA expression, were accessed.RESULTS:
The main findings revealed that the HLHS diet dramatically altered liver metabolism inducing hepatic steatosis and increased total cholesterol, triglycerides, VLDL, increasing liver CCAAT/enhancer binding protein (CEBP-α), Acetyl-CoA carboxylase (ACC) and Catalase (CAT) mRNA expression. Moreover, the HLHS diet increased glucose intolerance and reduced insulin sensitivity.CONCLUSIONS:
High-fat/high-sugar diets are efficient to induce obesity and metabolic syndrome-associated alterations, and diets enriched with lard and sugar showed more effective results.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndrome Metabólica
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Arch Physiol Biochem
Ano de publicação:
2023
Tipo de documento:
Article