Systemic overexpression of interleukin-22 induces the negative immune-regulator SOCS3 and potently reduces experimental arthritis in mice.

Aarts, Joyce; Roeleveld, Debbie M; Helsen, Monique M; Walgreen, Birgitte; Vitters, Elly L; Kolls, Jay; van de Loo, Fons A; van Lent, Peter L; van der Kraan, Peter M; Koenders, Marije I

Aarts, Joyce; Roeleveld, Debbie M; Helsen, Monique M; Walgreen, Birgitte; Vitters, Elly L; Kolls, Jay; van de Loo, Fons A; van Lent, Peter L; van der Kraan, Peter M; Koenders, Marije I.

Afiliação

Aarts J; Department of Experimental Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands.
Roeleveld DM; Department of Experimental Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands.
Helsen MM; Department of Experimental Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands.
Walgreen B; Department of Experimental Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands.
Vitters EL; Department of Experimental Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands.
Kolls J; Medicine, Tulane University School of Medicine, New Orleans, LA, USA.
van de Loo FA; Department of Experimental Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands.
van Lent PL; Department of Experimental Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands.
van der Kraan PM; Department of Experimental Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands.
Koenders MI; Department of Experimental Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands.

Rheumatology (Oxford) ; 60(4): 1974-1983, 2021 04 06.

Article em En | MEDLINE | ID: mdl-33197269

Assuntos

Artrite Experimental/terapia; Interleucinas/metabolismo; Proteína 3 Supressora da Sinalização de Citocinas/metabolismo; Animais; Artrite Experimental/imunologia; Artrite Experimental/metabolismo; Artrite Experimental/patologia; Modelos Animais de Doenças; Feminino; Articulações/patologia; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Endogâmicos DBA; Reação em Cadeia da Polimerase em Tempo Real; Proteína 3 Supressora da Sinalização de Citocinas/imunologia; Interleucina 22

Palavras-chave

IL-22; cytokines; experimental arthritis; inflammation; rheumatoid arthritis

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Experimental / Interleucinas / Proteína 3 Supressora da Sinalização de Citocinas Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Rheumatology (Oxford) Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google