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Clinical Actionability of the Genomic Landscape of Metastatic Castration Resistant Prostate Cancer.
Devlies, Wout; Eckstein, Markus; Cimadamore, Alessia; Devos, Gaëtan; Moris, Lisa; Van den Broeck, Thomas; Montironi, Rodolfo; Joniau, Steven; Claessens, Frank; Gevaert, Thomas.
Afiliação
  • Devlies W; Department of Urology, University Hospitals Leuven, 3000 Leuven, Belgium.
  • Eckstein M; Laboratory of Molecular Endocrinology, KU Leuven, 3000 Leuven, Belgium.
  • Cimadamore A; Department of Pathology, Friedrich-Alexander-University of Erlangen-Nürnberg, 91054 Erlangen, Germany.
  • Devos G; Section of Pathological Anatomy, School of Medicine, Polytechnic University of the Marche Region, United Hospitals, 60121 Ancona, Italy.
  • Moris L; Department of Urology, University Hospitals Leuven, 3000 Leuven, Belgium.
  • Van den Broeck T; Department of Urology, University Hospitals Leuven, 3000 Leuven, Belgium.
  • Montironi R; Laboratory of Molecular Endocrinology, KU Leuven, 3000 Leuven, Belgium.
  • Joniau S; Department of Urology, University Hospitals Leuven, 3000 Leuven, Belgium.
  • Claessens F; Section of Pathological Anatomy, School of Medicine, Polytechnic University of the Marche Region, United Hospitals, 60121 Ancona, Italy.
  • Gevaert T; Department of Urology, University Hospitals Leuven, 3000 Leuven, Belgium.
Cells ; 9(11)2020 11 17.
Article em En | MEDLINE | ID: mdl-33212909
The development of targeted therapies increases treatment options for metastatic castration resistant prostate cancer (mCRPC) patients. There is a need for strong predictive and prognostic signatures to guide physicians in treating mCRPC patients. In this review we unravel the possible actionability in the AR pathway, PI3K AKT signaling, and DNA repair pathways. Additionally, we make recommendations on biomarker trial design, and the clinical use of this new type of data.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Androgênicos / Biomarcadores Tumorais / Neoplasias de Próstata Resistentes à Castração / Metástase Neoplásica Tipo de estudo: Diagnostic_studies / Guideline / Prognostic_studies Limite: Humans / Male Idioma: En Revista: Cells Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Androgênicos / Biomarcadores Tumorais / Neoplasias de Próstata Resistentes à Castração / Metástase Neoplásica Tipo de estudo: Diagnostic_studies / Guideline / Prognostic_studies Limite: Humans / Male Idioma: En Revista: Cells Ano de publicação: 2020 Tipo de documento: Article