Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment.

Zhang, Rui; Li, Heng; Zhang, Xianglei; Li, Jian; Su, Haixia; Lu, Qiukai; Dong, Guangyu; Dou, Huixia; Fan, Chen; Gu, Zhanni; Mu, Qianwen; Tang, Wei; Xu, Yechun; Liu, Hong

Zhang, Rui; Li, Heng; Zhang, Xianglei; Li, Jian; Su, Haixia; Lu, Qiukai; Dong, Guangyu; Dou, Huixia; Fan, Chen; Gu, Zhanni; Mu, Qianwen; Tang, Wei; Xu, Yechun; Liu, Hong.

Afiliação

Zhang R; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China.
Li H; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China; Laboratory of Anti-inflammation and Immunopharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China.
Zhang X; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China; State Key Laboratory of Drug Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203, China.
Li J; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China.
Su H; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China; State Key Laboratory of Drug Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203, China.
Lu Q; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China; Laboratory of Anti-inflammation and Immunopharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China.
Dong G; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China.
Dou H; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China; State Key Laboratory of Drug Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203, China.
Fan C; Laboratory of Anti-inflammation and Immunopharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China.
Gu Z; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China.
Mu Q; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China; State Key Laboratory of Drug Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203, China.
Tang W; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China; Laboratory of Anti-inflammation and Immunopharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China. Electronic address: tangwei@simm.ac.cn.
Xu Y; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China; State Key Laboratory of Drug Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203, China. Electronic address: ycxu@simm.ac
Liu H; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China. Electronic addr

Eur J Med Chem ; 211: 113004, 2021 Feb 05.

Article em En | MEDLINE | ID: mdl-33218684

Assuntos

Anti-Inflamatórios não Esteroides/farmacologia; Nucleotídeo Cíclico Fosfodiesterase do Tipo 4/metabolismo; Desenho de Fármacos; Inibidores da Fosfodiesterase 4/farmacologia; Psoríase/tratamento farmacológico; Tetra-Hidroisoquinolinas/farmacologia; Animais; Anti-Inflamatórios não Esteroides/síntese química; Anti-Inflamatórios não Esteroides/química; Cristalografia por Raios X; Relação Dose-Resposta a Droga; Feminino; Humanos; Lipopolissacarídeos/antagonistas & inibidores; Lipopolissacarídeos/farmacologia; Camundongos; Camundongos Endogâmicos BALB C; Modelos Moleculares; Estrutura Molecular; Inibidores da Fosfodiesterase 4/síntese química; Inibidores da Fosfodiesterase 4/química; Psoríase/metabolismo; Células RAW 264.7; Relação Estrutura-Atividade; Tetra-Hidroisoquinolinas/síntese química; Tetra-Hidroisoquinolinas/química; Fator de Necrose Tumoral alfa/antagonistas & inibidores; Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

Antipsoriasis; PDE4 inhibitors; Tetrahydroisoquinoline

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Psoríase / Desenho de Fármacos / Anti-Inflamatórios não Esteroides / Tetra-Hidroisoquinolinas / Nucleotídeo Cíclico Fosfodiesterase do Tipo 4 / Inibidores da Fosfodiesterase 4 Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2021 Tipo de documento: Article

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