Dopamine transporter SPECT imaging in Parkinson's disease and parkinsonian disorders
Turk J Med Sci
; 51(2): 400-410, 2021 04 30.
Article
em En
| MEDLINE
| ID: mdl-33237660
ABSTRACT
The dopamine transporter (DAT) imaging provides an objective tool for the assessment of dopaminergic function of presynaptic terminals which is valuable for the differential diagnosis of parkinsonian disorders related to a striatal dopaminergic deficiency from movement disorders not related a striatal dopaminergic deficiency. DAT imaging with single-photon emission computed tomography (SPECT) can be used to confirm or exclude a diagnosis of dopamine deficient parkinsonism in cases where the diagnosis is unclear. It can also detect the dopaminergic dysfunction in presymptomatic subjects at risk for Parkinson's disease (PD) since the reduced radiotracer binding to DATs in striatum is already present in the prodromal stage of PD. This review covers the rationale of using DAT SPECT imaging in the diagnosis of PD and other parkinsonian disorders, specifically focusing on the practical aspects of imaging and routine clinical indications.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Dopamina
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Tomografia Computadorizada de Emissão de Fóton Único
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Corpo Estriado
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Proteínas da Membrana Plasmática de Transporte de Dopamina
/
Transtornos dos Movimentos
Tipo de estudo:
Diagnostic_studies
Limite:
Female
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Humans
/
Male
Idioma:
En
Revista:
Turk J Med Sci
Ano de publicação:
2021
Tipo de documento:
Article