Altered Mitochondria Functionality Defines a Metastatic Cell State in Lung Cancer and Creates an Exploitable Vulnerability.

Chuang, Chen-Hua; Dorsch, Madeleine; Dujardin, Philip; Silas, Sukrit; Ueffing, Kristina; Hölken, Johanna M; Yang, Dian; Winslow, Monte M; Grüner, Barbara M

Chuang, Chen-Hua; Dorsch, Madeleine; Dujardin, Philip; Silas, Sukrit; Ueffing, Kristina; Hölken, Johanna M; Yang, Dian; Winslow, Monte M; Grüner, Barbara M.

Afiliação

Chuang CH; Department of Genetics, Stanford University School of Medicine, Stanford, California.
Dorsch M; Department of Medical Oncology, West German Cancer Center, University Hospital Essen at the University of Duisburg-Essen, Essen, Germany.
Dujardin P; Department of Medical Oncology, West German Cancer Center, University Hospital Essen at the University of Duisburg-Essen, Essen, Germany.
Silas S; Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California.
Ueffing K; Department of Medical Oncology, West German Cancer Center, University Hospital Essen at the University of Duisburg-Essen, Essen, Germany.
Hölken JM; Department of Medical Oncology, West German Cancer Center, University Hospital Essen at the University of Duisburg-Essen, Essen, Germany.
Yang D; Cancer Biology Program, Stanford University School of Medicine, Stanford, California.
Winslow MM; Department of Genetics, Stanford University School of Medicine, Stanford, California.
Grüner BM; Cancer Biology Program, Stanford University School of Medicine, Stanford, California.

Cancer Res ; 81(3): 567-579, 2021 02 01.

Article em En | MEDLINE | ID: mdl-33239425

Assuntos

Adenocarcinoma/genética; Modelos Animais de Doenças; Neoplasias Pulmonares/genética; Mitocôndrias/genética; Adenocarcinoma/metabolismo; Adenocarcinoma/patologia; Animais; Linhagem Celular Tumoral; Perfilação da Expressão Gênica/métodos; Regulação Neoplásica da Expressão Gênica; Estudo de Associação Genômica Ampla/métodos; Humanos; Neoplasias Pulmonares/metabolismo; Neoplasias Pulmonares/patologia; Camundongos Knockout; Camundongos Transgênicos; Mitocôndrias/metabolismo; Metástase Neoplásica; Interferência de RNA

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Adenocarcinoma / Modelos Animais de Doenças / Neoplasias Pulmonares / Mitocôndrias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cancer Res Ano de publicação: 2021 Tipo de documento: Article

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