Triptolidenol, isolated from Tripterygium wilfordii, disrupted NF-&#954;B/COX-2 pathway by targeting ATP-binding sites of IKKß in clear cell renal cell carcinoma.

Jin, Junmei; Zhou, Meirong; Wang, Xun; Liu, Min; Huang, Huilian; Yan, Fei; Yu, Zhenlong; Shu, Xiaohong; Huo, Xiaokui; Feng, Lei; Zhang, Baojing; Huang, Shanshan; Deng, Sa; Wang, Chao; Ma, Xiaochi

Triptolidenol, isolated from Tripterygium wilfordii, disrupted NF-κB/COX-2 pathway by targeting ATP-binding sites of IKKß in clear cell renal cell carcinoma.

Jin, Junmei; Zhou, Meirong; Wang, Xun; Liu, Min; Huang, Huilian; Yan, Fei; Yu, Zhenlong; Shu, Xiaohong; Huo, Xiaokui; Feng, Lei; Zhang, Baojing; Huang, Shanshan; Deng, Sa; Wang, Chao; Ma, Xiaochi.

Afiliação

Jin J; Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China; Academy of Integrative Medicine, College of Pharmacy, Dalian Medical University, The Third People's Hospital of Dalian, Non-Directly Affiliated Hospital of Dali
Zhou M; Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China; Academy of Integrative Medicine, College of Pharmacy, Dalian Medical University, The Third People's Hospital of Dalian, Non-Directly Affiliated Hospital of Dali
Wang X; Academy of Integrative Medicine, College of Pharmacy, Dalian Medical University, The Third People's Hospital of Dalian, Non-Directly Affiliated Hospital of Dalian Medical University, Dalian 116044, China.
Liu M; Academy of Integrative Medicine, College of Pharmacy, Dalian Medical University, The Third People's Hospital of Dalian, Non-Directly Affiliated Hospital of Dalian Medical University, Dalian 116044, China; Neurology Department, Dalian University Affiliated Xinhua Hospital, Dalian 116021, China.
Huang H; Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
Yan F; Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
Yu Z; Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China; Academy of Integrative Medicine, College of Pharmacy, Dalian Medical University, The Third People's Hospital of Dalian, Non-Directly Affiliated Hospital of Dali
Shu X; Academy of Integrative Medicine, College of Pharmacy, Dalian Medical University, The Third People's Hospital of Dalian, Non-Directly Affiliated Hospital of Dalian Medical University, Dalian 116044, China.
Huo X; Academy of Integrative Medicine, College of Pharmacy, Dalian Medical University, The Third People's Hospital of Dalian, Non-Directly Affiliated Hospital of Dalian Medical University, Dalian 116044, China.
Feng L; Academy of Integrative Medicine, College of Pharmacy, Dalian Medical University, The Third People's Hospital of Dalian, Non-Directly Affiliated Hospital of Dalian Medical University, Dalian 116044, China.
Zhang B; Academy of Integrative Medicine, College of Pharmacy, Dalian Medical University, The Third People's Hospital of Dalian, Non-Directly Affiliated Hospital of Dalian Medical University, Dalian 116044, China.
Huang S; Academy of Integrative Medicine, College of Pharmacy, Dalian Medical University, The Third People's Hospital of Dalian, Non-Directly Affiliated Hospital of Dalian Medical University, Dalian 116044, China.
Deng S; Academy of Integrative Medicine, College of Pharmacy, Dalian Medical University, The Third People's Hospital of Dalian, Non-Directly Affiliated Hospital of Dalian Medical University, Dalian 116044, China.
Wang C; Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China. Electronic address: wach_edu@sina.com.
Ma X; Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.

Fitoterapia ; 148: 104779, 2021 Jan.

Article em En | MEDLINE | ID: mdl-33242535

Assuntos

Antineoplásicos Fitogênicos/farmacologia; Carcinoma de Células Renais/patologia; Diterpenos/farmacologia; Neoplasias Renais/patologia; Lactonas/farmacologia; Tripterygium/química; Trifosfato de Adenosina/metabolismo; Antineoplásicos Fitogênicos/isolamento & purificação; Apoptose/efeitos dos fármacos; Sítios de Ligação; Carcinoma de Células Renais/tratamento farmacológico; Caspases/metabolismo; Pontos de Checagem do Ciclo Celular/efeitos dos fármacos; Linhagem Celular Tumoral; Movimento Celular/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Ciclo-Oxigenase 2/metabolismo; Diterpenos/isolamento & purificação; Humanos; Quinase I-kappa B/metabolismo; Neoplasias Renais/tratamento farmacológico; Lactonas/isolamento & purificação; Simulação de Acoplamento Molecular; Estrutura Molecular; NF-kappa B/metabolismo; Compostos Fitoquímicos/isolamento & purificação; Compostos Fitoquímicos/farmacologia; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

COX-2; Clear cell renal cell carcinoma; IKKß; NF- κB; Triptolidenol

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Carcinoma de Células Renais / Tripterygium / Diterpenos / Neoplasias Renais / Lactonas / Antineoplásicos Fitogênicos Limite: Humans Idioma: En Revista: Fitoterapia Ano de publicação: 2021 Tipo de documento: Article

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