Toxicologic Pathology Forum: Opinion on Obligatory Microscopic Examination of Intermediate-Dose Groups in Toxicity Studies With Biotherapeutics in Cynomolgus Monkeys.

Parrula, Cecilia; Dincer, Zuhal; Geoly, Frank J; De Vera Mudry, Maria Cristina; Mysore, Jagannatha; Wuersch, Kuno

Parrula, Cecilia; Dincer, Zuhal; Geoly, Frank J; De Vera Mudry, Maria Cristina; Mysore, Jagannatha; Wuersch, Kuno.

Afiliação

Parrula C; Preclinical Safety Evaluation, 2184Vertex Pharmaceuticals Incorporated, Boston, MA, USA.
Dincer Z; Pathology, 63899Covance Laboratories Limited, Harrogate, United Kingdom.
Geoly FJ; 105623Worldwide Research & Development, Pfizer Inc, Groton, CT, USA.
De Vera Mudry MC; 1529Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center, Basel, Switzerland.
Mysore J; Drug Safety Evaluation, 3971Bristol-Myers Squibb, New Brunswick, NJ, USA.
Wuersch K; PreClinical Safety, 98560Novartis AG, Basel, Switzerland.

Toxicol Pathol ; 48(8): 939-943, 2020 12.

Article em En | MEDLINE | ID: mdl-33252033

Assuntos

Microscopia; Animais; Cães; Macaca fascicularis; Estudos Retrospectivos

Palavras-chave

biotherapeutics; cynomolgus; dose group; dose relationship; histopathology; nonclinical; nonrodent

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Microscopia Tipo de estudo: Observational_studies Limite: Animals Idioma: En Revista: Toxicol Pathol Ano de publicação: 2020 Tipo de documento: Article

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