Current Fertility Preservation Options for Female Patients With Hodgkin Lymphoma.
Obstet Gynecol Surv
; 75(11): 683-691, 2020 Nov.
Article
em En
| MEDLINE
| ID: mdl-33252698
ABSTRACT
IMPORTANCE Many adolescents and young adults diagnosed with Hodgkin lymphoma (HL) experience disease progression requiring high-dose alkylating salvage therapy, which often results in permanent infertility. OBJECTIVE:
The aim of this report is to discuss fertility preservation options in female patients with consideration of chemotherapeutic agents in HL. EVIDENCE ACQUISITION An electronic literature review was performed utilizing a combination of the terms "Hodgkin lymphoma," "fertility preservation," "ovarian tissue cryopreservation," "oocyte cryopreservation," "embryo cryopreservation," and "gonadotropin-releasing hormone agonist." References and data from identified sources were searched and compiled to complete this review.RESULTS:
Initial treatment of HL is often nonsterilizing; however, salvage therapy and conditioning for stem cell transplantation confer significant gonadotoxicity. Established fertility preservation options for pubertal females include embryo cryopreservation and oocyte cryopreservation. These options are contraindicated within 6 months of receipt of chemotherapy. Ovarian tissue cryopreservation is an option for patients who require salvage therapy within 6 months of first-line therapy.CONCLUSIONS:
Timing and choice of fertility preservation techniques depends on planned first-line chemotherapy and response to treatment. In patients initially treated with low-risk chemotherapy, it is reasonable to defer invasive fertility techniques until treatment failure; however, upfront fertility preservation should be considered in patients planning to undergo primary treatment with high-risk therapy.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
/
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Doença de Hodgkin
/
Antineoplásicos Alquilantes
/
Preservação da Fertilidade
/
Infertilidade Feminina
Tipo de estudo:
Prognostic_studies
Limite:
Female
/
Humans
Idioma:
En
Revista:
Obstet Gynecol Surv
Ano de publicação:
2020
Tipo de documento:
Article