Eltrombopag inhibits the proliferation of Ewing sarcoma cells via iron chelation and impaired DNA replication.

Waters, Torin; Goss, Kelli L; Koppenhafer, Stacia L; Terry, William W; Gordon, David J

Waters, Torin; Goss, Kelli L; Koppenhafer, Stacia L; Terry, William W; Gordon, David J.

Afiliação

Waters T; Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of Iowa, 25 S Grand Avenue, Iowa City, Iowa, 52242, USA.
Goss KL; Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of Iowa, 25 S Grand Avenue, Iowa City, Iowa, 52242, USA.
Koppenhafer SL; Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of Iowa, 25 S Grand Avenue, Iowa City, Iowa, 52242, USA.
Terry WW; Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of Iowa, 25 S Grand Avenue, Iowa City, Iowa, 52242, USA.
Gordon DJ; Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of Iowa, 25 S Grand Avenue, Iowa City, Iowa, 52242, USA. david-j-gordon@uiowa.edu.

BMC Cancer ; 20(1): 1171, 2020 Nov 30.

Article em En | MEDLINE | ID: mdl-33256675

Assuntos

Benzoatos/uso terapêutico; Replicação do DNA/genética; Hidrazinas/uso terapêutico; Quelantes de Ferro/uso terapêutico; Pirazóis/uso terapêutico; Sarcoma de Ewing/tratamento farmacológico; Benzoatos/farmacologia; Proliferação de Células; Humanos; Hidrazinas/farmacologia; Quelantes de Ferro/farmacologia; Pirazóis/farmacologia

Palavras-chave

Eltrombopag; Ewing sarcoma; Iron chelation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Sarcoma de Ewing / Benzoatos / Quelantes de Ferro / Replicação do DNA / Hidrazinas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: BMC Cancer Ano de publicação: 2020 Tipo de documento: Article

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