Inactive variants of death receptor p75<sup>NTR</sup> reduce Alzheimer's neuropathology by interfering with APP internalization.

Yi, Chenju; Goh, Ket Yin; Wong, Lik-Wei; Ramanujan, Ajeena; Tanaka, Kazuhiro; Sajikumar, Sreedharan; Ibáñez, Carlos F

Inactive variants of death receptor p75^NTR reduce Alzheimer's neuropathology by interfering with APP internalization.

Yi, Chenju; Goh, Ket Yin; Wong, Lik-Wei; Ramanujan, Ajeena; Tanaka, Kazuhiro; Sajikumar, Sreedharan; Ibáñez, Carlos F.

Afiliação

Yi C; Department of Physiology, National University of Singapore, Singapore City, Singapore.
Goh KY; Life Sciences Institute, National University of Singapore, Singapore City, Singapore.
Wong LW; Department of Physiology, National University of Singapore, Singapore City, Singapore.
Ramanujan A; Life Sciences Institute, National University of Singapore, Singapore City, Singapore.
Tanaka K; Department of Physiology, National University of Singapore, Singapore City, Singapore.
Sajikumar S; Life Sciences Institute, National University of Singapore, Singapore City, Singapore.
Ibáñez CF; Department of Physiology, National University of Singapore, Singapore City, Singapore.

EMBO J ; 40(2): e104450, 2021 01 15.

Article em En | MEDLINE | ID: mdl-33258176

Assuntos

Doença de Alzheimer/metabolismo; Precursor de Proteína beta-Amiloide/metabolismo; Proteínas do Tecido Nervoso/metabolismo; Transporte Proteico/fisiologia; Receptores de Fator de Crescimento Neural/metabolismo; Secretases da Proteína Precursora do Amiloide/metabolismo; Peptídeos beta-Amiloides/metabolismo; Animais; Linhagem Celular; Córtex Cerebral/metabolismo; Modelos Animais de Doenças; Células HEK293; Hipocampo/metabolismo; Humanos; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Neuritos/metabolismo; Neurônios/metabolismo; Placa Amiloide/metabolismo; Receptores de Morte Celular/metabolismo

Palavras-chave

A-beta; BACE; amyloid; endocytosis; neurodegeneration

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 / 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Precursor de Proteína beta-Amiloide / Receptores de Fator de Crescimento Neural / Transporte Proteico / Doença de Alzheimer / Proteínas do Tecido Nervoso Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: EMBO J Ano de publicação: 2021 Tipo de documento: Article

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