Development of Human Vectored Brucellosis Vaccine Formulation: Assessment of Safety and Protectiveness of Influenza Viral Vectors Expressing <i>Brucella</i> Immunodominant Proteins in Mice and Guinea Pigs.

Bugybayeva, Dina; Ryskeldinova, Sholpan; Zinina, Nadezhda; Sarmykova, Makhpal; Assanzhanova, Nurika; Kydyrbayev, Zhailaubay; Tabynov, Kaissar

Development of Human Vectored Brucellosis Vaccine Formulation: Assessment of Safety and Protectiveness of Influenza Viral Vectors Expressing Brucella Immunodominant Proteins in Mice and Guinea Pigs.

Bugybayeva, Dina; Ryskeldinova, Sholpan; Zinina, Nadezhda; Sarmykova, Makhpal; Assanzhanova, Nurika; Kydyrbayev, Zhailaubay; Tabynov, Kaissar.

Afiliação

Bugybayeva D; Research Institute for Biological Safety Problems, 15 Momushuly, Gvardeyskiy 080409, Kazakhstan.
Ryskeldinova S; Research Institute for Biological Safety Problems, 15 Momushuly, Gvardeyskiy 080409, Kazakhstan.
Zinina N; Research Institute for Biological Safety Problems, 15 Momushuly, Gvardeyskiy 080409, Kazakhstan.
Sarmykova M; Research Institute for Biological Safety Problems, 15 Momushuly, Gvardeyskiy 080409, Kazakhstan.
Assanzhanova N; Research Institute for Biological Safety Problems, 15 Momushuly, Gvardeyskiy 080409, Kazakhstan.
Kydyrbayev Z; Research Institute for Biological Safety Problems, 15 Momushuly, Gvardeyskiy 080409, Kazakhstan.
Tabynov K; Kazakh National Agrarian University, 8 Abay Avenue, Almaty 050010, Kazakhstan.

Biomed Res Int ; 2020: 1438928, 2020.

Article em En | MEDLINE | ID: mdl-33274194

Assuntos

Vacina contra Brucelose/imunologia; Brucelose/imunologia; Brucelose/prevenção & controle; Composição de Medicamentos; Vetores Genéticos/efeitos adversos; Epitopos Imunodominantes/metabolismo; Influenza Humana/virologia; Proteínas/metabolismo; Animais; Peso Corporal; Brucella melitensis/imunologia; Brucella melitensis/patogenicidade; Chlorocebus aethiops; Cobaias; Humanos; Imunização; Imunização Secundária; Camundongos; Células Vero; Virulência

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 / 2_ODS3 / 3_ND / 4_TD Base de dados: MEDLINE Assunto principal: Brucelose / Vacina contra Brucelose / Proteínas / Epitopos Imunodominantes / Composição de Medicamentos / Influenza Humana / Vetores Genéticos Limite: Animals / Humans Idioma: En Revista: Biomed Res Int Ano de publicação: 2020 Tipo de documento: Article

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