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Structure-Based Virtual Screening of Ultra-Large Library Yields Potent Antagonists for a Lipid GPCR.
Sadybekov, Arman A; Brouillette, Rebecca L; Marin, Egor; Sadybekov, Anastasiia V; Luginina, Aleksandra; Gusach, Anastasiia; Mishin, Alexey; Besserer-Offroy, Élie; Longpré, Jean-Michel; Borshchevskiy, Valentin; Cherezov, Vadim; Sarret, Philippe; Katritch, Vsevolod.
Afiliação
  • Sadybekov AA; Michelson Center for Convergent Biosciences, Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA.
  • Brouillette RL; Department of Chemistry, Bridge Institute, University of Southern California, Los Angeles, CA 90089, USA.
  • Marin E; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
  • Sadybekov AV; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, 141701 Dolgoprudny, Russia.
  • Luginina A; Department of Chemistry, Bridge Institute, University of Southern California, Los Angeles, CA 90089, USA.
  • Gusach A; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, 141701 Dolgoprudny, Russia.
  • Mishin A; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, 141701 Dolgoprudny, Russia.
  • Besserer-Offroy É; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, 141701 Dolgoprudny, Russia.
  • Longpré JM; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
  • Borshchevskiy V; Department of Pharmacology and Therapeutics, McGill University, Montreal, QC H3G 1Y6, Canada.
  • Cherezov V; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
  • Sarret P; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, 141701 Dolgoprudny, Russia.
  • Katritch V; Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich GmbH, 52425 Jülich, Germany.
Biomolecules ; 10(12)2020 12 03.
Article em En | MEDLINE | ID: mdl-33287369
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de Leucotrienos / Avaliação Pré-Clínica de Medicamentos / Bibliotecas de Moléculas Pequenas Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Humans Idioma: En Revista: Biomolecules Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de Leucotrienos / Avaliação Pré-Clínica de Medicamentos / Bibliotecas de Moléculas Pequenas Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Humans Idioma: En Revista: Biomolecules Ano de publicação: 2020 Tipo de documento: Article