SIRT1 - a new mammalian substrate of nuclear autophagy.
Autophagy
; 17(2): 593-595, 2021 02.
Article
em En
| MEDLINE
| ID: mdl-33292048
ABSTRACT
Macroautophagic/autophagic degradation of nuclear components (or nuclear autophagy) is a poorly understood area in autophagy research. We previously reported the nuclear lamina protein LMNB1 (lamin B1) as a nuclear autophagy substrate in primary human cells, stimulating the investigation of nuclear autophagy in the mammalian system. We recently reported the sirtuin protein SIRT1 as a new selective substrate of nuclear autophagy in senescence and aging. Upon senescence of primary human cells, SIRT1 degradation is mediated by a direct nuclear SIRT1-LC3 interaction, followed by nucleus-to-cytoplasm shuttling of SIRT1 and autophagosome-lysosome degradation. In vivo, SIRT1 is downregulated by lysosomes in hematopoietic and immune organs upon natural aging in mice and in aged human T cells. Our study identified another substrate of nuclear autophagy and suggests a new strategy to promote SIRT1-mediated health benefits by suppressing its autophagic degradation.Abbreviations HSPC hematopoietic stem and progenitor cells; NAD+ nicotinamide adenine dinucleotide; SASP senescence-associated secretory phenotype.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autofagia
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Núcleo Celular
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Autofagossomos
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Lisossomos
Limite:
Animals
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Humans
Idioma:
En
Revista:
Autophagy
Ano de publicação:
2021
Tipo de documento:
Article