Four new polyhydroxylated steroids from the South Sea sponge Plakortis sp.
Chin J Nat Med
; 18(11): 844-849, 2020 Nov.
Article
em En
| MEDLINE
| ID: mdl-33308606
ABSTRACT
Four new polyhydroxylated steroids plaksterols A-D (1-4), together with two known related steroids ergost-7,9(11),22-trien-3ß,5α,6α-triol (5) and ergosta-6ß-methoxy-7,22-diene-3ß,5α-diol (6), were isolated from methanol extract of the South China Sea marine sponge Plakortis sp. Their structures were identified by spectroscopic analysis, including NMR, MS, and IR. The cytotoxicity of the polyhydroxylated steroids were evaluated, and compound 6 showed moderate inhibitory activities against K562, HL-60 and BEL-7402 cells.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esteroides
/
Plakortis
Limite:
Animals
/
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Chin J Nat Med
Ano de publicação:
2020
Tipo de documento:
Article