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Four new polyhydroxylated steroids from the South Sea sponge Plakortis sp.
Wang, Kun-Ya; Li, Ping-Lin; Sun, Jing-Fan; de Voogd, Nicole J; Tang, Xu-Li; Li, Guo-Qiang.
Afiliação
  • Wang KY; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China; Laboratory of Marine Drugs and Biological Products, National Laboratory of Marine Science and Technology, Qingdao 266235, China.
  • Li PL; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China; Laboratory of Marine Drugs and Biological Products, National Laboratory of Marine Science and Technology, Qingdao 266235, China.
  • Sun JF; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China; Laboratory of Marine Drugs and Biological Products, National Laboratory of Marine Science and Technology, Qingdao 266235, China.
  • de Voogd NJ; National Museum of Natural History, PO Box 9517, 2300 RA Leiden, the Netherlands.
  • Tang XL; College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, China. Electronic address: tangxuli@ouc.edu.cn.
  • Li GQ; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China; Laboratory of Marine Drugs and Biological Products, National Laboratory of Marine Science and Technology, Qingdao 266235, China. Electronic address: liguo
Chin J Nat Med ; 18(11): 844-849, 2020 Nov.
Article em En | MEDLINE | ID: mdl-33308606
ABSTRACT
Four new polyhydroxylated steroids plaksterols A-D (1-4), together with two known related steroids ergost-7,9(11),22-trien-3ß,5α,6α-triol (5) and ergosta-6ß-methoxy-7,22-diene-3ß,5α-diol (6), were isolated from methanol extract of the South China Sea marine sponge Plakortis sp. Their structures were identified by spectroscopic analysis, including NMR, MS, and IR. The cytotoxicity of the polyhydroxylated steroids were evaluated, and compound 6 showed moderate inhibitory activities against K562, HL-60 and BEL-7402 cells.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esteroides / Plakortis Limite: Animals / Humans País/Região como assunto: Asia Idioma: En Revista: Chin J Nat Med Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esteroides / Plakortis Limite: Animals / Humans País/Região como assunto: Asia Idioma: En Revista: Chin J Nat Med Ano de publicação: 2020 Tipo de documento: Article