Respiratory outcomes of "new" bronchopulmonary dysplasia in adolescents: A multicenter study.
Pediatr Pulmonol
; 56(5): 1205-1214, 2021 05.
Article
em En
| MEDLINE
| ID: mdl-33314679
ABSTRACT
OBJECTIVE:
Long-term respiratory consequences of bronchopulmonary dysplasia (BPD) in preterm infants born in the post-surfactant era ("new" BPD) remain partially unknown. The present study aimed to evaluate the respiratory outcomes of "new" BPD in adolescents who were born preterm.METHODS:
This multicenter, cross-sectional study included 286 adolescents born between 2003 and 2005 (mean age 14.2 years); among them, 184 and 102 were born extremely preterm (EP; <28 weeks' gestation) and moderate-late preterm (32 to <37 weeks' gestation), respectively. Among EP adolescents, 92 had BPD, and 92 did not. All participants underwent lung function tests, skin prick testing, and questionnaires on asthma symptoms and quality of life.RESULTS:
EP adolescents with BPD had significantly lower forced expiratory volume in 1 s (FEV1 ), forced vital capacity (FVC), FEV1 /FVC ratio, and forced expiratory flow between 25% and 75% of FVC than other included adolescents. FEV1 /FVC ratios were below the lower limit of normal (z-score <-1.645) in 30.4% of EP adolescents with BPD, 13.0% of EP adolescents without BPD, and 11.8% of adolescents who were born moderate-late preterm. Bronchodilator response and air-trapping were significantly higher in BPD adolescents than in other adolescents. Diffusion capacity was significantly lower in EP adolescents than in moderate-late preterm adolescents. Asthma symptoms and quality-of-life scores were similar among groups.CONCLUSION:
EP adolescents with "new" BPD had poorer pulmonary function than EP adolescents without BPD or moderate-late preterm adolescents. Further studies are needed to determine whether "new" BPD is associated with early-onset chronic obstructive pulmonary disease in adulthood.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Displasia Broncopulmonar
Tipo de estudo:
Clinical_trials
/
Observational_studies
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Prevalence_studies
/
Risk_factors_studies
Aspecto:
Patient_preference
Limite:
Adolescent
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Female
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Humans
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Pregnancy
Idioma:
En
Revista:
Pediatr Pulmonol
Ano de publicação:
2021
Tipo de documento:
Article