Mechanisms mediating suppression of globin gene transcription in Danio rerio nonerythroid cells.
Biochimie
; 181: 96-99, 2021 Feb.
Article
em En
| MEDLINE
| ID: mdl-33321129
ABSTRACT
We studied the repression of adult and embryo-larval genes of the major globin gene locus in D. rerio fibroblasts. The results obtained suggest that at least some of the globin genes are repressed by Polycomb, similarly to human α-globin genes. Furthermore, within two α/ß globin gene pairs, repression of α-type and ß-type genes appears to be mediated by different mechanisms, as increasing the level of histone acetylation can activate transcription of only ß-type genes.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transcrição Gênica
/
Peixe-Zebra
/
Proteínas de Peixe-Zebra
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Alfa-Globinas
/
Globinas beta
Limite:
Animals
Idioma:
En
Revista:
Biochimie
Ano de publicação:
2021
Tipo de documento:
Article