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Survival Outcomes Following Combination of First-Line Platinum-Based Chemotherapy with S-1 in Patients with Advanced Gastric Cancer.
Koumarianou, Anna; Ntavatzikos, Anastasios; Vallilas, Christos; Kampoli, Katerina; Kakoseou, Zoi; Karamouzis, Michalis V.
Afiliação
  • Koumarianou A; Hematology Oncology Unit, Fourth Department of Internal Medicine, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Haidari, Greece.
  • Ntavatzikos A; Hematology Oncology Unit, Fourth Department of Internal Medicine, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Haidari, Greece.
  • Vallilas C; Molecular Oncology Unit, Department of Biological Chemistry & First Department of Internal Medicine, "Laiko" General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
  • Kampoli K; Hematology Oncology Unit, Fourth Department of Internal Medicine, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Haidari, Greece.
  • Kakoseou Z; Molecular Oncology Unit, Department of Biological Chemistry & First Department of Internal Medicine, "Laiko" General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
  • Karamouzis MV; Molecular Oncology Unit, Department of Biological Chemistry & First Department of Internal Medicine, "Laiko" General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Cancers (Basel) ; 12(12)2020 Dec 15.
Article em En | MEDLINE | ID: mdl-33333977
The efficacy of S-1 combined with a platinum agent in the first-line setting and in patients with advanced gastric adenocarcinoma has been previously demonstrated in randomized clinical trials. However, real-world data regarding S-1 efficacy in European patients remains limited. In the present study, we reviewed the data of a European cohort of patients with advanced gastric cancer treated with first-line therapy consisting of S-1 in combination with a platinum agent. Forty-eight patients (29 with locally advanced/inoperable and 19 with metastatic disease) were treated with S-1 plus oxaliplatin (33 patients) or S1 plus cisplatin (15 patients). The Cox regression analysis, adjusted with propensity score, indicated that the use of cisplatin as compared to oxaliplatin was associated with increased risk of death (HR 9.634, p = 0.000). Four SAEs (serious adverse events) GIII were recorded (1 fatigue, 1 neutropenia, 1 anemia, 1 diarrhea) in 3 patients. S-1 combination with a platinum agent in the first-line setting in European patients with advanced gastric cancer results to similar survival outcomes and toxicity with previously reported data from Asian populations. S-1 combination with oxaliplatin seems to be associated with superior efficacy as compared to cisplatin.
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 3_ND Base de dados: MEDLINE Tipo de estudo: Clinical_trials Idioma: En Revista: Cancers (Basel) Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 3_ND Base de dados: MEDLINE Tipo de estudo: Clinical_trials Idioma: En Revista: Cancers (Basel) Ano de publicação: 2020 Tipo de documento: Article