Regulation of macrophage subsets and cytokine production in leishmaniasis.
Cytokine
; 147: 155309, 2021 11.
Article
em En
| MEDLINE
| ID: mdl-33334669
ABSTRACT
Macrophages are host cells for parasites of the genus Leishmania where they multiply inside parasitophorous vacuoles. Paradoxically, macrophages are also the cells responsible for killing or controlling parasite growth, if appropriately activated. In this review, we will cover the patterns of macrophage activation and the mechanisms used by the parasite to circumvent being killed. We will highlight the impacts of the vector bite on macrophage activation. Finally, we will discuss the ontogeny of macrophages that are infected by Leishmania spp.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
/
3_ND
Base de dados:
MEDLINE
Assunto principal:
Leishmaniose
/
Citocinas
/
Macrófagos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cytokine
Ano de publicação:
2021
Tipo de documento:
Article