Effects of Cryopreservation on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Assessing Drug Safety Response Profiles.

Zhang, Joe Z; Belbachir, Nadjet; Zhang, Tiejun; Liu, Yu; Shrestha, Rajani; Wu, Joseph C

Zhang, Joe Z; Belbachir, Nadjet; Zhang, Tiejun; Liu, Yu; Shrestha, Rajani; Wu, Joseph C.

Afiliação

Zhang JZ; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Belbachir N; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Zhang T; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Liu Y; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Shrestha R; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Wu JC; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA; Molecular Imaging Program at Stanford, Department of Radiology, Stanford University Sc

Stem Cell Reports ; 16(1): 168-181, 2021 01 12.

Article em En | MEDLINE | ID: mdl-33338435

Assuntos

Criopreservação; Miócitos Cardíacos/metabolismo; Potenciais de Ação; Antiarrítmicos/farmacologia; Cálcio/metabolismo; Proteínas de Ciclo Celular/genética; Proteínas de Ciclo Celular/metabolismo; Diferenciação Celular; Sobrevivência Celular/efeitos dos fármacos; Avaliação Pré-Clínica de Medicamentos/métodos; Humanos; Células-Tronco Pluripotentes Induzidas/citologia; Células-Tronco Pluripotentes Induzidas/metabolismo; Miócitos Cardíacos/citologia; Miócitos Cardíacos/fisiologia; Nifedipino/farmacologia; Regulação para Cima/efeitos dos fármacos

Palavras-chave

cardiac arrhythmia; cryopreservation; drug response; drug safety assessment; hiPSC-CMs; microelectrode arrays; recovery

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Criopreservação / Miócitos Cardíacos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Stem Cell Reports Ano de publicação: 2021 Tipo de documento: Article

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